Science at life’s service
The progress made every day in the field of reproduction means that it’s imperative that we constantly update our scientific knowledge.
Clínica Tambre has been working for 40 years to increase its knowledge on assisted reproduction and has pioneered research on male factor infertility and abnormalities in sperm quality. We’ve helped thousands of couples make their dreams of having a child come true.
Research in Collaboration with Universities
Clínica Tambre lives by the motto research means knowledge, knowledge means help, which is why we are currently collaborating on several lines of research with prestigious Spanish and foreign universities including:
- The Complutense University of Madrid
- The Autonomous University of Madrid
- The University of San Francisco
- The University of Philadelphia
- The University of Palermo
- The University of Badajoz
- The University of Alicante
Learn more about our scientific activity
Do you want to see some of our most significant research?
1. Studies on Male Factor Infertility
Men with Azoospermia
The study of men with azoospermia, i.e., men who have no sperm in their ejaculate, is one of the lines of research that Clínica Tambre has pioneered and which it has been working on for years.
Clínica Tambre has developed a technique for freezing testicular sperm which makes it not only possible to bypass a second testicular biopsy, but also to achieve high pregnancy rates with frozen sperm.
At Clínica Tambre we know that sperm is just as important as eggs in achieving pregnancy. Therefore, Clínica Tambre has been collaborating for many years with the Autonomous University of Madrid to study the DNA and integrity of spermatozoa.
Our research has led us to be the first to demonstrate how DNA fragmentation is a dynamic process as well as highlighting the importance of processing sperm samples in the lab as quickly as possible.
At Clínica Tambre we study all types of sperm abnormalities in men such as Kartagener Syndrome, also known as immotile ciliary syndrome, which is characterised by a lack of motile sperm.
Antioxidants and Sperm Quality
At Clínica Tambre we are aware of the impact that a man’s quality of life can have on the quality of his sperm. That’s why we’ve carried out multiple studies in collaboration with pharmaceutical companies to learn about the influence of certain antioxidant substances on male fertility.
We Discovered a Protein Linked to Male Fertility
Afamin is a protein related to diseases such as cancer, diabetes, hypertension, and pregnancy complications. However, it had previously never been linked to infertility. Afamin’s main role is to transport vitamin E to the organs that need it. Clínca Tambre’s research on this subject has linked this protein to a low sperm count and sperm motility.
This discovery will allow us to determine which men are eligible to undergo vitamin E treatment to increase their fertility.
This study was carried out in collaboration with the University of Vigo and Professor Roman Kireev.
2. Studies on Female Factor Infertility
The low number of oocytes produced by young women after ovarian stimulation is one of the greatest challenges for researchers at Clínica Tambre. Up until now multiple studies have shown that oxidative stress is, in many cases, the cause of this low response. To verify whether antioxidant treatment is the most suitable option for these types of patients, a clinical trial with melatonin is currently being carried out.
To see the complete research paper, click on the publications below:
Publication nº1 – Oxidative Stress
Publication nº3 – Antioxidant Gene
Implantation failure is one of the lesser-known causes that makes pregnancy impossible.
Clínica Tambre was the first clinic to incorporate an immunology service for its patients: The immunological factors that may prevent pregnancy are studied by a specialist in the field, enabling them to prescribe the appropriate therapy.
Multiple studies on this topic have been published in collaboration with other clinics including the Gregorio Marañón Hospital in Madrid
To see the complete research paper and the results of our collaboration, click on the publications below:
Publication nº1 – Intravenous-Immunoglobulin
Publication nº2 – New Decision Tree Model
We also wanted to learn about the differences between an infertile woman’s endometrium and that of a fertile donor. We collaborated with the University of Palermo on this topic. To see the results of our collaboration, click here
3. Studies on Couples
Results on Children Born through Assisted Reproduction
At Clínica Tambre your pregnancy isn’t our only concern, we also want to ensure that you have a healthy child at home. That’s why year after year we study the results of the pregnancies achieved at our clinic and also why we care so much about the health of those newborn babies. This research, done primarily by our nurses, has been presented at several national conferences
Lipids and Infertility
Clínica Tambre is currently working on a study that demonstrates the influence of lipid levels on sperm and egg count.
See the study – Lipid Dysregulation in Seminal and Follicular Fluids related with Male and Female Infertility
4. Laboratory Studies
The Influence of Incubator Oxygen Levels on Embryo Growth
We were the first clinic to use low-oxygen incubators, which guarantee optimum results for embryo development until the blastocyst stage.
Tambre carried out a study to measure the effects of micro-environments on thawed embryos and to compare incubators with different oxygen levels. The study concluded that the use of low concentrations of O2 in their micro-environment is recommended for the development of cryopreserved embryos on day +3 because it increases pregnancy rates.
See the study – (In spanish)
Time Lapse Incubators
We were also the first clinic to use GERI incubators, which enable the monitoring of embryo growth without having to take the slide out of the incubator. The studies carried out using these incubators have demonstrated that their use increases the number of high-quality embryos for transfer. Click here to see the process and conclusions of our research.
5. Sociological Studies
Gamete Donor Profile
All donors that come to the Clinic for sperm and egg donation undergo an evaluation which helps us get to know them better. This evaluation lets us know why they’ve come into the clinic, where they’ve come from, and what their occupation is.
Due to our interest in this topic, Clínica Tambre was involved in drawing up the recommendations published by the Spanish Fertility Society (SEF in Spanish) (http://www.sefertilidad.net/docs/grupos/etica/propuestaBases.pdf), and we have also participated in numerous conferences and forums as subject material experts.
If you’d like to find out more, click on the link to see the complete study on the ethical issues of Surrogate Pregnancy which was presented by Dr.Rocío Nuñez Calonge in Lisbon in May 2018.
6. Ethical Studies
At Clínica Tambre we believe that ethical issues are strongly tied to assisted reproduction. We are the only private assisted reproduction clinic that has a Health Care Ethics Committee authorised by the Community of Madrid
Our Scientific Director Dr. Rocío Núñez has a Masters degree in Bioethics and has published multiple research papers which deal with bioethics and reproduction, such as “Problemas éticos en reproducción asistida”(Ethical Issues in Assisted Reproduction), published in the Revista Iberoamericana de Fertilidad (Ibero-American Fertility Magazine).