Our Clinic is well known for its commitment to scientific development and Research and were delighted to be invited to participate in the recent, renowned ‘Fertility 2021’ Congress, organised by the Association of Reproductive & Clinical Scientists, the British Fertility Society and the Society for Reproduction & Fertility.
Fertility 2021 Online: ‘Barriers and breakthroughs’
This year’s Congress, like so many over the last year, took place online. This, however, did not detract from the quality of the event which reflected the organiser’s mission to disseminate innovative and quality content. As its official website explains, the congress programme was designed to offer a platform for specialists in fertility and reproductive biology from around the world, to facilitate the sharing of research and knowledge and to highlight developments in treatment and service provision aimed at improving the patient experience.
Fertility 2021 Online: Tambre’s participation
At the previous Congress in 2020, Carolina Andrés, an Embryologist from Tambre, exhibited the short paper, ‘NLRP3 Inflammasome activation in low ovarian reserve patients’ (prepared by Andrés Santé, Carolina; Rancan, L; Cordero Rosales, C; Rodrigo Carbajosa, A; Linillos Pradillo, B; Vara Ameigeiras, E; Tresguerres, JAF; Cortés Gallego, S)
This year, our Embryologist returned to ‘Fertility 2021’ with the short paper, ‘Altered mitochondrial biogenesis in poor ovarian response patients’, a work completed with, Beatriz Linillos Pradillo, Lisa Rancan, Carolina Cordero Rosales, Carmen Rodriguez Roque, Elena Vara Ameigeiras, Jesús A.F. Tresguerres and Susana Cortés Gallego.
This study focusses on a group of patients categorized as ‘low responders’ because they do not respond adequately to stimulation with gonadotropins, which is associated with a low pregnancy rate. The pathophysiological mechanisms behind this low response are yet to be defined and therefore this area of research is one which is attracting a lot of research work.
Opening new pathways for patients with low ovarian reserve
Mitochondrial biogenesis is essential during the oocyte generation process and its association with different pathologies and the aging process has been identified within scientific literature.
“Our objective is to evaluate whether this pathway is altered in the granulosa cells of patients with a low response, which could be of interest for possible future alternative markers that measure oocyte quality. We evaluated key molecules of the pathway, such as PGC-1α (peroxisome-proliferator-activated receptor γ co-activator-1α), NRF1 and NRF2 or TFAM and observed that they were significantly reduced,” concludes Carolina Andrés.
The Tambre team always strives to be at the forefront of scientific activity and progression both within Spain and internationally, and we will continue to contribute and participate in all the conferences and congresses it can. In doing so, we commit to fulfilling the objective of helping to develop the most effective strategies and treatments designed to improve the prognosis of those who dream of starting a family.